<form id="form1" runat="server">
<asp:ScriptManager ID="ScriptManager1" runat="server">
</asp:ScriptManager>
<asp:UpdatePanel ID="UpdatePanel1" runat="server" UpdateMode="Conditional">
<ContentTemplate>
<%= DateTime.Now %>
<asp:Button ID="Button1" runat="server" Text="Button" />
</ContentTemplate>
</asp:UpdatePanel>
<hr />
<asp:UpdatePanel ID="UpdatePanel2" runat="server" UpdateMode="Conditional">
<ContentTemplate>
<%= DateTime.Now %>
<asp:Button ID="Button2" runat="server" Text="Button" />
</ContentTemplate>
</asp:UpdatePanel>
</form>
In this code, Button1 will only update UpdatePanel1, Button2 will only update UpdatePanel2.