<asp:UpdatePanel ID="UpdatePanel1" runat="server" UpdateMode="Conditional">
<ContentTemplate>
<%= DateTime.Now %>
<asp:UpdatePanel ID="UpdatePanel2" runat="server">
<ContentTemplate>
<%= DateTime.Now %>
<asp:Button ID="Button1" runat="server" Text="Button" />
</ContentTemplate>
</asp:UpdatePanel>
</ContentTemplate>
</asp:UpdatePanel>
In this code, Button1 will not update UpdatePanel1.