<asp:UpdatePanel ID="UpdatePanel1" runat="server" ChildrenAsTriggers="false" UpdateMode="Conditional">
<ContentTemplate>
<%= DateTime.Now %>
<asp:Button ID="Button1" runat="server" Text="Button" />
<asp:Button ID="Button2" runat="server" Text="Button" />
</ContentTemplate>
<Triggers>
<asp:AsyncPostBackTrigger ControlID="Button1" />
</Triggers>
</asp:UpdatePanel>
In this code, Button1 will update UpdatePanel1, Button2 will not update UpdatePanel1.